Nine sets you can't get anywhere else. Infect every city on a continent in Pandemic Game Mode and that continent's full five-piece set arrives at Legendary, along with 3 RNA strands. Its item level is 20 plus 6 for each continent you've infected. Infect the whole world for the Prismatic Pandemic Crown set and 9 RNA strands.
North America's set: more loot, more shots, more damage.
Pieces: Liberty Crown, Mantle, Lattice, Talons and Lance (full Legendary set)
(3) +15% nucleotides
(4) +1 projectile on every shot (40% damage)
(5) +25% damage
Continent requirement: Level 2
From the Codex
In 1907 cook Mary Mallon, 'Typhoid Mary', was found to be a healthy carrier of typhoid who had infected the families she worked for. She was quarantined on North Brother Island in the East River.
Fun fact: United States · population 19.5 million · North America
Pieces: Old World Crown, Mantle, Lattice, Talons and Lance (full Legendary set)
(3) Detection rises 25% slower
(4) +10% critical hit chance
(5) +30% damage
Continent requirement: Level 4 · Gen 3
From the Codex
In 1854 a cholera outbreak in Soho killed over 600 people. Doctor John Snow mapped the deaths around the Broad Street water pump and had its handle removed, founding modern epidemiology.
Fun fact: United Kingdom · population 9.6 million · Europe
Dubai's airport handles more international passengers than any other on Earth. In April 2020, with its flights grounded, the city turned its World Trade Centre into a 3,000-bed field hospital in a matter of days.
Fun fact: United Arab Emirates · population 3.7 million · Middle East
In 1980 a man sick with Marburg virus travelled to Nairobi Hospital. A doctor who treated him caught it too but survived, a case later made famous by the book The Hot Zone.
In 1999 the South Pole Station's only doctor, Jerri Nielsen, found a lump in her breast and treated herself with chemotherapy drugs airdropped in the dark of winter.
Fun fact: Research base · population 150 · Antarctica
(4) +1 projectile, fire 20% faster, Detection rises 30% slower
(5) Shots pierce 2 more cells, regenerate 3 HP/s, take 15% less damage, +30% damage
From the Codex
How the world fights back in Pandemic Game Mode: every city, its continent and the world answer your spread with responses that change every run you play there.
Fun fact: Every response card on the world map says exactly what it changes; tap a diamond on a city's timeline to jump to that card. The breaking-news ticker lists every response in force, newest first.