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Nucleotides pay for most things; RNA and Ribozyme Cores are rare drops tied to Pandemic Game Mode and Endless Game Mode.

On this page11
  1. Adenine (A)
  2. Thymine (T)
  3. Cytosine (C)
  4. Guanine (G)
  5. Where nucleotides come from
  6. RNA Strand
  7. Polymerase Shard
  8. Chaperone Protein
  9. Ribozyme Core
  10. Enhancement costs
  11. Rare DNA

Adenine (A)

Nucleotide

The most common base: about 35% of nucleotide drops.

  • Petri Lab upgrades, gear combining and run modifiers
From the Codex

The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).

Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.

Nucleotide in the Codex

Thymine (T)

Nucleotide

About 30% of nucleotide drops.

  • Petri Lab upgrades, gear combining and run modifiers
From the Codex

The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).

Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.

Nucleotide in the Codex

Cytosine (C)

Nucleotide

About 22% of nucleotide drops.

  • Petri Lab upgrades, gear combining and run modifiers
From the Codex

The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).

Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.

Nucleotide in the Codex

Guanine (G)

Nucleotide

The scarcest base: only about 13% of nucleotide drops.

  • Advanced upgrades and many costs lean on it
From the Codex

The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).

Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.

Nucleotide in the Codex

Nucleotide piles drop from every cell you kill, plus chests, challenges, Endless Game Mode sets and dismantled gear.

  • Up to 20 nucleotides gather into one pickup
  • Uncollected pickups stay in their room if you leave and come back
From the Codex

The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).

Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.

Nucleotide in the Codex

RNA Strand

Pandemic only

A rare purple drop that unlocks advanced Lab upgrades, pays for every third Lab level and buys skill tree respecs.

  • Drops only in Pandemic Game Mode; anywhere else it breaks down into nucleotides
  • About 1 in 120 kills, about 1 in 4 Killer T cells, about 2 in 5 bosses and tumor fights and about 1 in 6 receptor puzzles
  • About a third of a strand per person infected (a whole one every few people), +1 per city taken, +3 per continent, +9 for the whole world
From the Codex

Ribonucleic acid: a single-stranded cousin of DNA that carries genetic messages and, in many viruses, the whole genome.

Fun fact: Some RNA molecules can act as enzymes (ribozymes), which hints that early life may have run on RNA alone.

RNA in the Codex

The common enhancement material; every enhancement level needs some.

  • About 1 in 5 kills, elite cells, vesicle chests and every challenge
  • +4 per person infected in Pandemic Game Mode
  • Also used to craft many run modifiers
From the Codex

The enzyme that copies a virus's genome. RNA viruses carry their own RNA-dependent RNA polymerase, which cells don't have.

Fun fact: Because cells lack this enzyme, it's a prime drug target: remdesivir and favipiravir both jam viral polymerases.

Viral Polymerase in the Codex

The uncommon enhancement material.

  • Killer T cells, bosses (3 to 5), vesicle chests, puzzles and Normal-or-harder challenges
  • +3 per city taken in Pandemic Game Mode
  • Also used to craft many run modifiers
From the Codex

Helper proteins (like heat-shock proteins) that guide other proteins into their correct folded shape.

Fun fact: Many viruses hijack host chaperones such as HSP70 and HSP90 to fold their own proteins.

Chaperone Proteins in the Codex

Ribozyme Core

Endless only

The rare enhancement material, needed to enhance gear from +3 up to +10.

  • Only drops in Endless Game Mode: every set pays at least one, plus its bosses, Killer T cells and elites
  • Elsewhere these drops condense into Chaperones
  • +1 per city taken in Pandemic Game Mode
  • Needed for 9 run modifiers
From the Codex

RNA molecules that act as enzymes, cutting and joining RNA without any protein help.

Fun fact: The ribosome's core catalytic site is a ribozyme, a living fossil of an early "RNA world".

Ribozymes in the Codex

Each enhancement level from +1 to +10 costs more materials, scaled up for rarer and higher-level gear.

  • Common gear: +1 costs 150 Shards and 1 Chaperone; +2 costs 300 Shards and 4 Chaperones
  • +3 costs 500 Shards, 9 Chaperones and 1 Ribozyme
  • +10 costs 4,700 Shards, 110 Chaperones and 32 Ribozymes
  • Rarer tiers multiply costs: ×1.3 Uncommon up to ×5 Prismatic, and Shards climb further (×1.3 more per tier, about ×4.8 more on Prismatic)
From the Codex

RNA molecules that act as enzymes, cutting and joining RNA without any protein help.

Fun fact: The ribosome's core catalytic site is a ribozyme, a living fossil of an early "RNA world".

Ribozymes in the Codex

Rare DNA

Collectible

A golden ancient retrovirus fragment that a solved receptor puzzle sometimes releases.

  • 25% chance per solved receptor puzzle

See also