
Resources
Currencies & Materials
Nucleotides pay for most things; RNA and Ribozyme Cores are rare drops tied to Pandemic Game Mode and Endless Game Mode.
On this page11
- Adenine (A)
- Thymine (T)
- Cytosine (C)
- Guanine (G)
- Where nucleotides come from
- RNA Strand
- Polymerase Shard
- Chaperone Protein
- Ribozyme Core
- Enhancement costs
- Rare DNA
The most common base: about 35% of nucleotide drops.
- Petri Lab upgrades, gear combining and run modifiers
From the Codex
The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).
Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.
Nucleotide in the CodexAbout 30% of nucleotide drops.
- Petri Lab upgrades, gear combining and run modifiers
From the Codex
The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).
Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.
Nucleotide in the CodexAbout 22% of nucleotide drops.
- Petri Lab upgrades, gear combining and run modifiers
From the Codex
The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).
Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.
Nucleotide in the CodexThe scarcest base: only about 13% of nucleotide drops.
- Advanced upgrades and many costs lean on it
From the Codex
The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).
Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.
Nucleotide in the CodexNucleotide piles drop from every cell you kill, plus chests, challenges, Endless Game Mode sets and dismantled gear.
- Up to 20 nucleotides gather into one pickup
- Uncollected pickups stay in their room if you leave and come back
From the Codex
The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).
Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.
Nucleotide in the CodexA rare purple drop that unlocks advanced Lab upgrades, pays for every third Lab level and buys skill tree respecs.
- Drops only in Pandemic Game Mode; anywhere else it breaks down into nucleotides
- About 1 in 120 kills, about 1 in 4 Killer T cells, about 2 in 5 bosses and tumor fights and about 1 in 6 receptor puzzles
- About a third of a strand per person infected (a whole one every few people), +1 per city taken, +3 per continent, +9 for the whole world
From the Codex
Ribonucleic acid: a single-stranded cousin of DNA that carries genetic messages and, in many viruses, the whole genome.
Fun fact: Some RNA molecules can act as enzymes (ribozymes), which hints that early life may have run on RNA alone.
RNA in the CodexThe common enhancement material; every enhancement level needs some.
- About 1 in 5 kills, elite cells, vesicle chests and every challenge
- +4 per person infected in Pandemic Game Mode
- Also used to craft many run modifiers
From the Codex
The enzyme that copies a virus's genome. RNA viruses carry their own RNA-dependent RNA polymerase, which cells don't have.
Fun fact: Because cells lack this enzyme, it's a prime drug target: remdesivir and favipiravir both jam viral polymerases.
Viral Polymerase in the CodexThe uncommon enhancement material.
- Killer T cells, bosses (3 to 5), vesicle chests, puzzles and Normal-or-harder challenges
- +3 per city taken in Pandemic Game Mode
- Also used to craft many run modifiers
From the Codex
Helper proteins (like heat-shock proteins) that guide other proteins into their correct folded shape.
Fun fact: Many viruses hijack host chaperones such as HSP70 and HSP90 to fold their own proteins.
Chaperone Proteins in the CodexThe rare enhancement material, needed to enhance gear from +3 up to +10.
- Only drops in Endless Game Mode: every set pays at least one, plus its bosses, Killer T cells and elites
- Elsewhere these drops condense into Chaperones
- +1 per city taken in Pandemic Game Mode
- Needed for 9 run modifiers
From the Codex
RNA molecules that act as enzymes, cutting and joining RNA without any protein help.
Fun fact: The ribosome's core catalytic site is a ribozyme, a living fossil of an early "RNA world".
Ribozymes in the CodexEach enhancement level from +1 to +10 costs more materials, scaled up for rarer and higher-level gear.
- Common gear: +1 costs 150 Shards and 1 Chaperone; +2 costs 300 Shards and 4 Chaperones
- +3 costs 500 Shards, 9 Chaperones and 1 Ribozyme
- +10 costs 4,700 Shards, 110 Chaperones and 32 Ribozymes
- Rarer tiers multiply costs: ×1.3 Uncommon up to ×5 Prismatic, and Shards climb further (×1.3 more per tier, about ×4.8 more on Prismatic)
From the Codex
RNA molecules that act as enzymes, cutting and joining RNA without any protein help.
Fun fact: The ribosome's core catalytic site is a ribozyme, a living fossil of an early "RNA world".
Ribozymes in the CodexA golden ancient retrovirus fragment that a solved receptor puzzle sometimes releases.
- 25% chance per solved receptor puzzle