Gut

Who you meet here

BossPaneth CellKeeper of the intestinal crypts, full of gold defensin granules. Expect spiralling defensin streams, mucus barrages…Key guardianCajal PacemakerThe gut's electrical pacemaker (Awakened), guarding the Mucolytic Enzyme. It sets the whole room contracting.GeneMucolytic EnzymeDissolves mucus plugs. Mucus no longer slows you.CancerColon CarcinomaA shell game: the core hides down in one of several crypts, surfaces in another to fire, then dives again. Polyps on…AssassinSignet-Ring BurrowerA cell whose nucleus is squashed to the rim by mucus. Almost completely invisible at range, though a little slower…

Organ facts

Objective

"Get past the Paneth Cell's defensins"

Boss

Paneth Cell, "Keeper of the intestinal crypts"

Key guardian

Cajal Pacemaker (Awakened), holding the Mucolytic Enzyme

Cancer

Colon Carcinoma (it hides in its crypts, so watch where it surfaces and dodge the polyps' pools). Its assassin is the Signet-Ring Burrower

Hazards

peristaltic waves that sweep the room

Local cells

Neutrophils, Goblet Cells, IgA Plasma Cells, Free Antibodies, Macrophages and Eosinophils. Deeper rooms add Helper T Cells, antiviral capsules and Complement

Look

a dark amber floor, swaying villi and drifting golden specks

Music

A Phrygian at 98 BPM, the darkest and most swung theme

Size

19–23 rooms

Threat

enemy damage ×3.2, enemy health ×6.5, rewards ×3.4

Also in the Gut

Tissue Hazards & TerrainOrgans & Bosses

PeristalsisEvery few seconds the gut wall clenches and a wave sweeps across the room, carrying everything with it.GutClots & Scar TissueSticky patches of clot left by dying platelets, fibrin attacks, goblet mucus and stellate scarring. They bog you right down.Bloodstream & deeper

Tumor PartsCancer

Colon coreA tan, cauliflower-like adenocarcinoma riddled with malformed glands. It moves between crypts under the floor.GutCryptA dark well in the gut lining, ringed by goblet cells, where the colon tumor hides.GutPolypA lumpy pink growth on a short stalk along the walls that drips caustic pools and buds more polyps.Gut

Tumor AttacksCancer

Crypt surfacingThe colon tumor bursts out of a flashing crypt. Don't stand on it.GutCaustic dripPolyps lob a glob toward you that leaves a caustic pool on the floor.Gut

RetrovirusViruses

KamikazesFrom the Gut on, every cell your shots kill adds a kamikaze to a store that releases itself when full.Gut milestone

Organ MilestonesViruses

Retrovirus: GutCaptured cells get +10% damage and +15% toughness, and every cell your shots kill adds a kamikaze.Organ 5Filovirus: GutBleeding gets 10% stronger, and Hemorrhage weakens cells 5% more.Organ 5Halovirus: GutSpike volleys deal 15% more, and the Fury surge gives +65% damage.Organ 5

The Organ MapIn a Run

GutGet past the Paneth Cell's defensins.Organ 5

Boss SetsGear & Store

Capsomere LatticeThe Paneth Cell's set, built to tank and punish contact.Organ 5 · Gut

Audio & PresentationGame Modes

Gut themeThe darkest theme, with the heaviest swing.Organ 5

Found in every organ

Abyss PitsBottomless gaps in the tissue. Falling in is a heavy blow, not instant death.Any organDrop ShaftsA rare glowing shaft in one of an organ's deeper fight rooms. Walk in and the current sweeps you into a freshly shuffled layout of the…Rare

From the Codex