Milestone Challenges

Combat

80 challenges

Kills, rooms, flawless fights, elites, ambushes and ability use.

• Destroy cells: First Blood, Infection, Outbreak, Epidemic, Pandemic, Extinction Event (then II to VII): 10 to 100,000 cells, E to L
• Destroy cells in one run: Viral Load, Cytokine Storm, Sepsis, Total Collapse (then II to V): 25 to 800, E to El
• Clear rooms: Explorer, Colonizer, Systemic, Every Corner (then II to VI): 5 to 2,000, E to El
• Clear rooms in one run: Deep Infection 30 (N), Organ Failure 60 (H)
• Fights without damage: Untouchable 5 (N), Ghost Strain 30 (H), Immune Blind Spot 150 (El)
• In one run: Clean Sweep 5 (H), Flawless Infection 12 (El)
• Elite (blue or better) kills: Elite Hunter, Antigen Breaker, Champion Slayer: 5 to 1,000, E to El
• By cell tier: Blue Blood 25 / Elite Purge 250; Purple Reign 10 / Epic Slayer 100; Golden Hunt 5 / Legend Killer 50; Red Alert 1 / Myth Breaker 10; Prism Breaker 1 / Prismatic Massacre 5
• Ambush kills: Sneak Attack, Silent Killer, Assassin Strain: 10 to 1,000, E to H
• Drug or vaccine particles: Drug Resistance, Antiviral Immunity, Untreatable: 10 to 1,000, E to H
• Ultimate: Pandemic Power 10 (E), Global Outbreak 100 (N)
• Signature ability: Shapeshifter 10 (E), Master of Disguise 100 (N)
• Dashes: Quick Spread, Jet Stream: 50 to 5,000, E to H
• Active skill: Skilled 50 (E), Ability Spammer 500 (N)

Enemies

202 challenges

A Hunter, Bane and Extinction chain for every immune cell type, plus host cells.

• Common cells (10 to 2,500 kills, E to H): Neutrophil, Free Antibody, Macrophage, B Cell, Monocyte, Plasmablast, Platelets
• Uncommon cells (5 to 1,000 kills, E to El): Natural Killer Cell, Dendritic Cell, Complement System, Helper T Cell, Follicular Dendritic Cell, Goblet Cell, IgA Plasma Cell, Stellate Cell, NKT Cell, Megakaryocyte, Myeloblast, Astrocyte, Resident Memory T Cell, Eosinophil, Basophil, Memory B Cell, Lymphoid Progenitor, Thymocyte
• Host cells: Cell Burster 100 (E), Lytic Feast 1,000 (N)

Bosses

53 challenges

Organ bosses, key guardians, tumors and boss feats.

• Boss kills: Giant Killer, Boss Rush, Warlord: 1 to 100, E to L
• In one run: Double Kill 2 (N), Gauntlet 4 (H), Clean House 8 (L)
• Each organ boss once (Slayer) and 5 times (Nemesis, one step harder): Mast Cell (E), Alveolar Macrophage (N), Plasma Cell (N), Follicular Helper T Cell (H), Paneth Cell (H), Kupffer Cell (El), Hematopoietic Stem Cell (El), Microglia (L)
• Tumors: Oncolytic 1 (N), Tumor Hunter 5 (H), Remission 20 (El)
• Key guardians: Gatebreaker 1 (E), Keymaster 10 (N), Warden Slayer 40 (H)
• Each guardian Down 1 (E) and Hunter 8 (N): Mucin Colossus, Syncytium, Fibrin Weaver, Reticular Warden, Cajal Pacemaker, Polyploid Hepatocyte, Giant Osteoclast, Betz Cell
• Bosses without damage: Untouched 1 (H), Boss Ghost 5 (El), Perfect Predator 20 (L)
• Bosses within 60 seconds: Speed Kill 1 (H), Blitz 10 (El)

Immune System

29 challenges

Killer T cells, sieges, treatments, Detection and stealth.

• Killer T cells: T-Cell Down 1 (N), Cytotoxic Breaker 10 (H), Adaptive Nightmare 50 (El)
• Immune Sieges: Hold the Line 1 (N), Siege Breaker 10 (H)
• Treatment doses: Drug Resistant 1 (N), Superbug 10 (H)
• Antiviral, vaccine and interferon doses: Resistant 3 (N), Immune 20 (H) for each
• Killer T generation in one run: They Keep Coming 3 (N), Adaptive Arms Race 5 (H), Immune Escalation 8 (El)
• Wanted: push Detection to 100 in one run (N)
• Immune level in one run: Provoked 5 (N), Full Alert 8 (H), Total War 12 (El)
• Hunter squads: Hunted, Most Wanted: 1 to 100, E to H
• Organs left with Detection never above 30: Ghost 1 (N), Silent Spread 10 (H), Never Seen 50 (El)

Rivals

11 challenges

Beat the other viruses competing for the host.

• Rival kills: Competition 1 (N), Apex Strain 5 (H), Only One Survives 25 (El)
• Rhinovirus, Norovirus and Adenovirus: Rival 1 (N), Nemesis 5 (H) each
• Rival generation in one run: Evolved Rival 3 (H), Ancient Rival 5 (El)

Map

53 challenges

Reaching organs, exploring every room and finding special rooms.

• Reach each organ in one run: Into the Lungs (E), Bloodstream (N), Lymph Node (N), Gut (H), Liver (H), Bone Marrow (El), Brain (L)
• Purge: destroy 500 cells in each organ (Nasal Passage E up to Brain El)
• Cartographer: explore every room of each organ in one run (E up to El)
• Discover rooms: Wanderer, Pathfinder, Atlas: 10 to 2,000, E to H
• Fully explore organs: Thorough 1 (E), Completionist 10 (N), Every Cell Counted 50 (H)
• Discover 5 (E) / 25 (N): Upgrade Chambers (Treasure Seeker, Vault Raider), trade-off altar rooms (Deal Maker, Faustian), Mutagenic Pools (Gambler, High Roller), refuges (Safe Haven, Sanctuary Regular), puzzle rooms (Curious, Puzzle Hunter), gene vaults (Gene Seeker, Vault Opener)
• Pit rooms: Edge Walker 10 (E), Abyss Dancer 100 (N)
• Receptor puzzles: Lock Pick 1 (E), Receptor Master 10 (N), Key to Everything 50 (H)
• Lysis Chambers: Burst Them 1 (N), Harvest Season 10 (H)

Hazards

20 challenges

Use the organs' own terrain.

• Nerve reflexes by touch: Ticklish 5 (E), Reflex Test 50 (N)
• Nerve reflexes by shots: Nerve Striker 10 (E), Neural Saboteur 100 (N)
• Drop shafts: Free Fall 1 (E), Shaft Diver 10 (N)
• Hazard kills: Environmental Hazard, Tissue Trap, Terrain Master: 10 to 500, E to H
• Red blood cells burst: Hemolysis 5 (E), Anaemia 50 (N)
• Reticular fibres snapped: Fibre Cutter 5 (E), Net Breaker 50 (N)
• Stem cell niches burst: Marrow Raider 3 (E), Niche Thief 25 (N)
• Incubation revives: Second Chance 1 (N), Unkillable 10 (H)

Pickups

84 challenges

Nucleotides, orbs, chests, power-ups, RNA and materials.

• Nucleotides: Base Pairs, Genome Bank, Nucleotide Baron: 100 to 250,000, E to El
• Mutation orbs: Mutation Magnet, Orb Collector, Orb Hoarder: 5 to 500, E to H
• Vesicle chests: Vesicle Opener, Chest Cracker, Vesicle Baron: 5 to 500, E to H
• Genes: Gene Splicer 5 (E), Genome Editor 50 (N)
• Trade-offs: Bargainer 5 (E), Pact Maker 50 (N)
• Dormant Virions: Dormant 1 (N), Sleeper Cell 10 (H)
• Power-ups: Powered Up, Elemental, Force of Nature: 1 to 250, E to H
• CRISPR: Gene Editor 1 (N), Cas9 Master 10 (H)
• Each element 1 (E), Adept 5 (N), Master 15 (H): Spike Shield, Chain Lightning, Fire Cross, Tidal Pulse, Gale Force, Stone Skin, Frost Aura, Mist Veil, Radiance, Umbra
• RNA strands: Strand Finder, RNA Collector, Genome Library: 1 to 200, E to H
• Enhancement materials: Scrapper, Material Hoard, Workshop Stock: 50 to 10,000, E to H

Traits

33 challenges

Take, stack and collect traits.

• Traits in one run: Mutant 10 (E), Hypermutator 20 (N), Chimera 35 (H)
• Traits overall: Gene Collector, Living Library: 10 to 1,000, E to El
• By type, 25 (E) / 150 (N): STAT (Stat Builder, Number Cruncher), EFFECT (Status Spreader, Plague Bringer), PROJECTILE (Bullet Bender, Projectile Master), DEFENCE (Shielded, Fortress), DASH (Dash Fiend, Blink Master), SURVIVAL (Survivor, Undying)
• Legendary traits: Golden Gene 1 (N), Legendary Genome 10 (H)
• Mythic traits: Mythic Mutation 1 (H), Myth Maker 5 (El)
• Prismatic trait: Prismatic Gene 1 (El)
• Stack one trait in a run: Doubling Down ×3 (E), Obsession ×5 (N), Single-Minded ×8 (H)
• Different traits in a run: Diverse Genome 8 (N), Swiss Army Virus 14 (H), Everything at Once 20 (El)

Gear

48 challenges

Find, forge, enhance and recycle gear.

• Find gear: Scavenger, Hoarder, Armory: 5 to 500, E to H
• Purple or better: Lucky Find 1 (N), Treasure Strain 10 (H), Legend Seeker 50 (El)
• Per slot, 25 (E) / 100 (N): Capsid, Envelope, Matrix, Tail Fibers, Spike Protein Collector and Connoisseur
• Rare finds: Feeling Blue 25 (E), Blue Collection 100 (N)
• Legendary finds: First Legendary 1 (H), Legendary Armory 10 (El)
• Mythic finds: Mythic Find 1 (El), Mythic Armory 5 (L); Prismatic Drop 1 (L)
• Boss set pieces: Boss Trophy 1, Set Collector 10, Full Wardrobe 40
• Enhance: Tinkerer 1, Engineer 25, Perfectionist 100; to +10: Perfected 1 (H), Master Smith 5 (El)
• Combine: Fusion 1, Recombinant 10, Chimeric Arsenal 40
• Forge by combining: Forge Rare (E), Forge Epic (N), Forge Legendary (H), Forge Mythic (El), Forge Prismatic (L)
• Gear mutations: Lucky Mutation 1 (N), Mutant Arsenal 10 (H)
• Dismantle: Recycler 10, Salvage King 100, Scrap Lord 500

Progression

24 challenges

Runs, wins, Lab levels and skill ranks.

• Petri Lab levels: Lab Rat 1 (E), Researcher 25 (N), Chief Scientist 100 (H)
• Skill ranks: Student 1 (E), Adept 25 (N), Grandmaster 80 (H)
• Runs played: Patient Zero, Persistent, Endemic: 1 to 250, E to El
• Wins: Host Infected 1 (El), Serial Infector 5 (El), Unstoppable 25 (L)
• Win as each virus: Influenza A, Retrovirus, Filovirus and Halovirus Victory 1 (El) and Dynasty 5 (L)