Wiki In a Run Drops & Pickups Loot on the floor
Drops & Pickups What cells, chests and rooms leave behind during a run. Pickups from one organ don't follow you into the next.
On this page 10 Mutation Orb Vesicle Chest Nucleotides Polymerase Shard Chaperone Protein Ribozyme Core RNA Strand Gear Dormant Virion Run Modifier Drop A glowing DNA orb: touch it to choose 1 of 3 traits for the rest of the run.
35% of cleared fights leave one Guaranteed from Mutation Chambers, solved puzzles, won Sieges and Lysis Chambers, destroyed tumors and Mutagenic rooms, and from every boss that opens a passage to the next organ (none from the Brain's boss or in Pandemic Game Mode, where the run ends) From the Codex A change in a genome's sequence. Most are harmless or harmful, and a few help the organism survive.
Fun fact: Flu's RNA polymerase doesn't proofread, so it makes errors constantly.
Mutation in the Codex A membrane bubble you walk into to burst open.
7% of cleared fights leave one, plus Mutation Chambers, puzzles, events and Hidden Cache rooms 40% hold gear; the rest hold extra nucleotides Always 3–6 Polymerase Shards and more nucleotides; half the time a Chaperone Protein A small chance of a Dormant Virion From the Codex Tiny membrane bubbles cells release to ship proteins and genetic material to other cells.
Fun fact: Some viruses hijack vesicles to travel hidden inside them, invisible to antibodies.
Extracellular Vesicles in the Codex Piles of A, T, C and G from every cell you kill, counted on the HUD during the run.
Roughly 35% Adenine, 30% Thymine, 22% Cytosine and only 13% Guanine Nearby piles merge, up to 20 per pickup Spent on Petri Lab upgrades, gear combining and more From the Codex The building block of DNA and RNA: a sugar, a phosphate and a base (A, T, C, G in DNA; A, U, C, G in RNA).
Fun fact: Influenza stores its genes as RNA, so it uses U in place of T.
Nucleotide in the Codex The common gear-enhancing material.
About 1 kill in 5 drops 1–2 Vesicle chests hold 3–6 From the Codex The enzyme that copies a virus's genome. RNA viruses carry their own RNA-dependent RNA polymerase, which cells don't have.
Fun fact: Because cells lack this enzyme, it's a prime drug target: remdesivir and favipiravir both jam viral polymerases.
Viral Polymerase in the Codex Enhances gear from +1 upward.
Bosses drop several, Killer T cells 2–3, solved puzzles 2 Half of all vesicle chests hold one From the Codex Helper proteins (like heat-shock proteins) that guide other proteins into their correct folded shape.
Fun fact: Many viruses hijack host chaperones such as HSP70 and HSP90 to fold their own proteins.
Chaperone Proteins in the Codex The rare material for enhancing gear from +3 to +10.
Only drops in Endless Game Mode In Infect and Pandemic Game Modes each one condenses into 2 Chaperone Proteins (1 when a kill drops it: kills pay chaperones at half) From the Codex RNA molecules that act as enzymes, cutting and joining RNA without any protein help.
Fun fact: The ribosome's core catalytic site is a ribozyme, a living fossil of an early "RNA world".
Ribozymes in the Codex A rare purple strand for advanced Petri Lab upgrades and skill tree respecs.
Only drops in Pandemic Game Mode: about 1 kill in 120, plus about 1 in 4 Killer T cells, 2 in 5 bosses and tumors and 1 in 6 puzzlesElsewhere it breaks down into nucleotides From the Codex Ribonucleic acid: a single-stranded cousin of DNA that carries genetic messages and, in many viruses, the whole genome.
Fun fact: Some RNA molecules can act as enzymes (ribozymes), which hints that early life may have run on RNA alone.
RNA in the Codex Equipable gear drops mid-run, with a NEW GEAR toast showing its level and tier.
Rare from ordinary cells, far likelier from elites, which also drop better tiers 20% of Killer T cells drop a piece Every boss drops one named set piece In Pandemic Game Mode bosses drop an ordinary piece of their tier instead, and every other gear drop is 84% rarer 40% of vesicle chests hold gear From the Codex The protein shell that encloses a virus's genome, built from repeating subunits called capsomeres. Most are icosahedral (20 triangular faces) or helical.
Fun fact: Capsids self-assemble: the proteins snap together on their own, like a puzzle that builds itself.
Capsid in the Codex A rare amber cyst labelled EXTRA LIFE: a stored incubation for this run.
Bosses 8% (not the final boss), rival viruses 6%+, tumors 4%, treatments 4%, Killer T cells 3%, Legendary-or-better elites 3%, chests 1% At most one per organ, each one this run makes the next rarer, and none while you hold 3 From the Codex The time between catching a virus and feeling sick. The virus is multiplying, but the body hasn't noticed yet, so there are no symptoms.
Fun fact: Flu incubates for about 1–4 days, measles about 10–12, and rabies can take months; HIV's silent clinical latency can last 10 years.
Incubation (Extra Life) in the Codex Once Run Modifiers unlock, a finished modifier can drop and go straight into your stock.
3% per cleared fight, 30% per boss, and a small chance from Rare-or-better elites Shows MODIFIER FOUND From the Codex Consumables crafted between runs that change the next run.
Fun fact: A loaded modifier stays loaded until you run out of it.
Run Modifiers in the Codex 
