Host conditions
Some hosts live with a condition that bends the whole run, each with a big upside and a big downside. 22% of people have one (plus 4% per tier above Common) and 30% of animals (plus 4% per tier). People get human conditions, each species has its own diseases, and every animal can catch the general ones.
Sugary blood: +60% nucleotides and immune cells 15% slower. But rooms heal you 70% less.
In type 1 diabetes the immune system destroys insulin-making cells; high blood sugar slows wound healing and weakens immune cells.
A condition people can have.
Type 1 Diabetes in the Codex
Weak immune system: cells have 45% less HP, there are fewer of them and far fewer elites. But you earn 40% fewer nucleotides.
Some people are born with a weakened immune system (like SCID, 'bubble boy disease') and catch infections far more easily.
A condition people can have.
Primary Immunodeficiency in the Codex
The immune system attacks itself: dying cells burst and hurt their neighbours, +50% nucleotides. But every cell starts alert and hits 30% harder.
Lupus is an autoimmune disease: the immune system attacks the body's own tissues, causing widespread inflammation.
A condition people can have.
Lupus (Autoimmune) in the Codex
Everything runs hot: you fire 25% faster and move 20% faster. But cells move 30% faster and their shots fly 25% faster.
A fever above about 41°C is a medical emergency. Fever speeds up immune cells, but extreme heat damages the body too.
A condition people can have.
Raging Fever in the Codex
The body is overwhelmed: double nucleotides and 50% more mutation orbs. But 70% more cells per room and 2 extra rooms per area.
Sepsis is the body's extreme, life-threatening response to an infection, when the immune response spirals out of control.
A condition people can have.
Sepsis in the Codex
Sickled red cells: you move 20% faster and land 15% critical hits. But you have 30% less max HP.
Sickle cell disease bends red blood cells into crescents; carrying one copy of the gene protects against malaria.
A condition people can have.
Sickle Cell Anemia in the Codex
Thick mucus everywhere: cells move 30% slower and see 30% less far. But you move 15% slower too.
Cystic fibrosis makes mucus thick and sticky, clogging the lungs and gut and trapping microbes.
A condition people can have.
Cystic Fibrosis in the CodexA stressed host: +50% nucleotides and 10% critical hits. But Detection starts at 30, rises 70% faster and barely cools.
Long-term stress and lack of sleep raise cortisol, which disrupts the immune system's normal rhythm.
A condition people can have.
Chronic Stress & Insomnia in the Codex
Blood won't clot: +40% damage. But clearing rooms never heals you.
In hemophilia a clotting factor is missing, so bleeding takes much longer to stop. It ran through Europe's royal families.
A condition people can have.
Hemophilia in the Codex
Allergic overreaction: +80% nucleotides, double RNA, many more elites. But cells have 30% more HP and hit 20% harder.
Anaphylaxis is a severe allergic reaction where mast cells release histamine all at once.
A condition people can have.
Severe Allergies in the Codex
Narrowed airways: cells move 20% slower, +30% nucleotides. But you move 10% slower and there are more pits.
In asthma the airways swell and narrow; respiratory viruses are a common trigger of attacks.
A condition people can have.
Severe Asthma in the Codex
An exhausted immune system: cells have 20% less HP and hit 15% softer. But far fewer mutation orbs and RNA.
Post-viral fatigue can leave people exhausted for months after an infection, with an immune system that hasn't fully settled.
A condition people can have.
Post-Viral Fatigue in the Codex
The host is riddled with cancer: every organ grows a tumor that starts a stage bigger, grows faster and spreads twice more. Tumors pay out triple and the run pays +30%.
Metastasis is when cancer spreads from where it started to other organs through the blood or lymph.
A condition people can have.
Metastatic Cancer in the Codex
The drugs wipe out immune cells (30% less HP, hit 20% softer) and shrink tumors (they take 50% more damage). But they poison you too: −20% max HP.
Chemotherapy kills fast-dividing cells: cancer, but also immune cells, which is why patients catch infections easily.
A condition people can have.
Chemotherapy in the Codex
Another virus is already here: you start with a random trait of the host's genome tier. But the immune system is primed: cells have 15% more HP.
Hosts are often infected with more than one virus at once; viruses sharing a cell can swap genes.
A condition people can have.
Viral Co-infection in the Codex
A fungus covers the bat: cells see half as far and +60% nucleotides. But you can only see a small circle around you.
White-nose syndrome is a fungal disease that has killed millions of North American bats since 2006.
Found in: Fruit Bat.
White-Nose Syndrome in the Codex
A rabid host: +30% damage. But every cell is already alert and moves 40% faster.
Rabies infects the brain and makes animals aggressive; it's nearly 100% fatal once symptoms start.
Found in: Fruit Bat, Dog, White-Tailed Deer, Reindeer.
Rabies in the Codex
Another virus lives here: you deal 15% less damage. But triple RNA and +50% nucleotides.
Fruit bats carry Nipah virus without getting sick; it has spilled over to pigs and people in Asia.
Found in: Fruit Bat, Pig.
Nipah Virus Carrier in the Codex
A hibernating bat: cells move half as fast and Detection rises half as fast. But the cold slows your fire rate 30%.
Hibernating bats drop their body temperature and immune activity, which lets fungi and viruses take hold.
Found in: Fruit Bat.
Hibernation Torpor in the CodexThe pig's cells are dying: they have 35% less HP. But 60% more of them per room.
African swine fever kills nearly all infected pigs and has spread across Asia and Europe since 2018.
Found in: Pig.
African Swine Fever in the CodexAs Influenza A: pig flu to swap genes with, +35% damage and double mutation orbs. As any other virus: a competing flu, −20% damage but +20% nucleotides.
Pigs catch both bird and human flu; the 2009 pandemic strain was assembled inside pigs.
Found in: Pig.
Swine Flu H1N1 in the Codex
Blistered tissue: cells that touch you take 15 damage, +30% nucleotides. But you move 15% slower.
Foot-and-mouth disease causes painful blisters in cattle and pigs; the 2001 UK outbreak led to millions of animals being culled.
Found in: Dairy Cow, Pig, Dromedary Camel, Kangaroo, Llama.
Foot-and-Mouth Disease in the Codex
Spongy, prion-riddled tissue: cells see 60% less far and Detection rises 60% slower. But the floor is full of holes.
Mad cow disease (BSE) is caused by misfolded prion proteins that leave the brain full of tiny holes.
Found in: Dairy Cow.
Mad Cow Disease in the Codex
Granulomas wall off infection: fewer cells, +60% nucleotides. But they have 40% more HP and elites are common.
Bovine tuberculosis forms granulomas, balls of immune cells walling off the bacteria.
Found in: Dairy Cow, Dromedary Camel, Llama.
Bovine Tuberculosis in the Codex
Tumorous tissue everywhere: cells have 20% less HP, +40% nucleotides. But 3 extra rooms per area.
Marek's disease is a herpesvirus of chickens that causes tumors; its vaccine was the first against a cancer.
Found in: Chicken.
Marek's Disease in the Codex
+30% nucleotides either way. As Influenza A: another flu to swap genes with, +40% damage, but cells have 20% more HP. As any other virus: −25% damage, but cells have 20% less HP.
H5N1 bird flu has spread worldwide in wild birds since 2021; when two flu strains meet, they can swap genes.
Found in: Chicken, Mallard Duck, Herring Gull, Pigeon, Penguin, Seal.
Avian Influenza H5N1 in the Codex
Nervous-system damage: cells move 30% slower. But every cell is already alert.
Newcastle disease is a paramyxovirus of poultry that attacks the nervous system.
Found in: Chicken, Pigeon.
Newcastle Disease in the Codex
Pox lesions: cells have 30% less HP. But wounded cells slowly regenerate.
Fowlpox is a poxvirus spread by mosquitoes that causes wart-like lesions on birds.
Found in: Chicken.
Fowlpox in the Codex
Paralysing toxin: cells move 45% slower. But you move 20% slower and fire 15% slower.
Botulism toxin, made by bacteria in stagnant water, paralyses waterbirds and kills thousands each year.
Found in: Mallard Duck, Herring Gull, Penguin.
Avian Botulism in the Codex
A haemorrhaging host: dying cells burst and hurt neighbours, +50% nucleotides. But the bursts can hurt you too.
Duck plague (duck viral enteritis) is a herpesvirus that causes internal bleeding in ducks and geese.
Found in: Mallard Duck.
Duck Plague in the Codex
A mosquito-borne brain infection: double RNA, cells see 40% less far. But they hit 25% harder.
West Nile virus cycles between birds and mosquitoes and can infect the brain of birds, horses and people.
Found in: Mallard Duck, Herring Gull, Pigeon.
West Nile Virus in the Codex
Slick feathers: you move 10% faster, dash 40% more often and enemy shots are 20% slower. But rooms heal you half as much.
Oil from spills mats seabird feathers, destroying their waterproofing and insulation.
Found in: Herring Gull, Penguin.
Oiled Feathers in the Codex
A dizzy, twitching host: you move 25% faster and dash 40% more often. But enemy shots fly 30% faster.
Pigeon paramyxovirus makes birds twitch, twist their necks and lose balance.
Found in: Pigeon.
Pigeon Paramyxovirus in the Codex
Weakened by distemper: cells have 25% less HP. But dying cells burst and can hurt you.
Canine distemper is a measles-like virus that attacks dogs' breathing, gut and nervous system.
Found in: Dog, Seal.
Canine Distemper in the CodexParvovirus wrecked the gut: cells have 40% less HP. But you have 25% less max HP.
Canine parvovirus attacks rapidly dividing cells in the gut and is often deadly to unvaccinated puppies.
Found in: Dog.
Canine Parvovirus in the CodexAs Influenza A: dog flu to mix with, you fire 25% faster and get +20% nucleotides. As any other virus: you fire 15% slower, but +30% nucleotides.
Canine influenza viruses jumped to dogs from horses (H3N8) and birds (H3N2).
Found in: Dog.
Canine Influenza in the Codex
A wasting deer: cells have 40% less HP. But you have 30% less max HP and cells hit 20% harder.
Chronic wasting disease is a prion disease of deer and elk that slowly wastes them away.
Found in: White-Tailed Deer, Reindeer.
Chronic Wasting Disease in the Codex
Haemorrhagic fever: dying cells burst and hurt neighbours, +40% nucleotides. But cells hit 25% harder.
Epizootic hemorrhagic disease, spread by biting midges, causes fever and bleeding in deer.
Found in: White-Tailed Deer, Reindeer.
Epizootic Hemorrhagic Disease in the Codex
Another virus already here: −10% damage. But cells have 30% less HP and Detection rises 30% slower.
Studies found human viruses spreading widely among wild white-tailed deer.
Found in: White-Tailed Deer.
Deer Virus Reservoir in the Codex
SIV already wrecked its defences: cells have 45% less HP and few elites. But you earn 20% fewer nucleotides.
Some SIV strains cause AIDS-like disease in monkeys and apes, just as HIV does in people.
Found in: Chimpanzee, Macaque, Capuchin Monkey, Ring-Tailed Lemur.
Simian Immunodeficiency in the Codex
The host is collapsing: 40% fewer cells with 30% less HP. But you have 25% less max HP and Detection starts at 40.
Ebola outbreaks have killed large numbers of wild chimpanzees and gorillas.
Found in: Chimpanzee.
Filovirus Outbreak in the Codex
Pox lesions: cells that touch you take 20 damage, 10% critical hits. But 30% more cells per room.
Mpox is a poxvirus that circulates in animals including primates and rodents and can spread to people.
Found in: Chimpanzee, Macaque, Capuchin Monkey, Ring-Tailed Lemur.
Mpox in the Codex
Worms steal the host's food: cells have 30% less HP. But you earn 30% fewer nucleotides.
Parasitic worms compete with their host for nutrients and can dampen immune responses.
Found in: Fruit Bat, Dairy Cow, Pig, Chicken, Dog, Mallard Duck, White-Tailed Deer, Herring Gull, Chimpanzee, Pigeon, Penguin, Seal, Dromedary Camel, Kangaroo, Macaque, Capuchin Monkey, Llama, Ring-Tailed Lemur, Reindeer.
Parasitic Worms in the Codex
A starving host: 30% fewer cells, and they're 10% slower. But you have 20% less max HP.
A poorly fed body makes fewer immune cells and fights infections less well.
Found in: Fruit Bat, Dairy Cow, Pig, Chicken, Dog, Mallard Duck, White-Tailed Deer, Herring Gull, Chimpanzee, Pigeon, Penguin, Seal, Dromedary Camel, Kangaroo, Macaque, Capuchin Monkey, Llama, Ring-Tailed Lemur, Reindeer.
Malnutrition in the Codex
Lungs full of bacteria: cells are distracted (see 40% less far), +30% nucleotides. But 40% more cells per room.
Bacterial pneumonia often follows a viral infection once the airways' defences are damaged.
Found in: Fruit Bat, Dairy Cow, Pig, Chicken, Dog, Mallard Duck, White-Tailed Deer, Herring Gull, Chimpanzee, Pigeon, Penguin, Seal, Dromedary Camel, Kangaroo, Macaque, Capuchin Monkey, Llama, Ring-Tailed Lemur, Reindeer.
Pneumonia in the Codex
Tick-borne inflammation: 10% critical hits, +40% nucleotides. But wounded cells regenerate.
Ticks spread Lyme disease bacteria, which cause long-lasting inflammation.
Found in: Fruit Bat, Dairy Cow, Pig, Chicken, Dog, Mallard Duck, White-Tailed Deer, Herring Gull, Chimpanzee, Pigeon, Penguin, Seal, Dromedary Camel, Kangaroo, Macaque, Capuchin Monkey, Llama, Ring-Tailed Lemur, Reindeer.
Lyme Disease (Ticks) in the Codex
An overheated host: you move 15% faster and dash 30% more often. But 15% less max HP and enemy shots fly 15% faster.
Overheating forces the body to divert resources, weakening immune defences.
Found in: Fruit Bat, Dairy Cow, Pig, Chicken, Dog, Mallard Duck, White-Tailed Deer, Herring Gull, Chimpanzee, Pigeon, Penguin, Seal, Dromedary Camel, Kangaroo, Macaque, Capuchin Monkey, Llama, Ring-Tailed Lemur, Reindeer.
Heat Stress in the Codex
Poisoned tissue: cells hit 25% softer and Detection rises 30% slower. But they have 25% more HP.
Lead from old bullets and fishing weights poisons wildlife and suppresses the immune system.
Found in: Fruit Bat, Dairy Cow, Pig, Chicken, Dog, Mallard Duck, White-Tailed Deer, Herring Gull, Chimpanzee, Pigeon, Penguin, Seal, Dromedary Camel, Kangaroo, Macaque, Capuchin Monkey, Llama, Ring-Tailed Lemur, Reindeer.
Lead Poisoning in the Codex
