Daily & Weekly Challenges

Daily Easy pool

16 challenges

One of these is the Easy daily.

• Morning Infection: destroy 60 cells
• Daily Rounds: clear 8 rooms
• Small Mutations: take 5 traits
• Gather Bases: collect 150 nucleotides
• Show of Force: use your ultimate 2 times
• On the Move: dash 40 times
• Pick It Up: find 2 pieces of gear
• Pick a Fight: destroy 3 elite cells
• Orb Snatcher: collect 3 mutation orbs
• Pop the Vesicles: open 3 vesicle chests
• Sightseeing: discover 12 rooms
• Neutrophil Cull: destroy 25 Neutrophils
• Antibody Sweep: destroy 40 Free Antibodies
• Ambusher: destroy 10 cells before they notice you
• Tickle the Nerves: set off 3 nerve reflexes with your shots
• Material Run: collect 20 enhancement materials

Daily Normal pool

16 challenges

One of these is the Normal daily.

• Busy Day: destroy 200 cells
• Long Shift: clear 20 rooms
• Boss of the Day: defeat 1 boss
• Clean Hands: clear 3 fights without taking damage
• Stand Your Ground: survive 1 Immune Siege
• Loot Run: find 4 pieces of gear
• Elite Hunt: destroy 8 elite cells
• Puzzle of the Day: solve 2 receptor puzzles
• Macrophage Hunt: destroy 15 Macrophages
• Shrug Off the Cure: destroy 15 drug or vaccine particles
• Stack It: stack one trait ×3 in a single run
• Kick the Nest: draw 2 hunter squads
• Explorer's Day: fully explore 1 organ
• Purple Hunt: destroy 2 Epic cells or better
• Make a Deal: accept 1 trade-off
• Dash Builder: take 2 DASH traits

Daily Hard pool

14 challenges

One of these is the Hard daily.

• Go Deep: reach organ 3 in a single run
• Double Trouble: defeat 2 bosses
• Flawless Day: clear 8 fights without taking damage
• Bring Down a Killer: destroy 1 Killer T cell
• One Long Fight: destroy 150 cells in a single run
• Rival Hunt: defeat 1 rival virus
• Cancer Day: destroy 1 tumor
• Resist the Cure: survive 1 treatment dose
• Untouchable Boss: defeat 1 boss without taking damage
• Ghost Day: leave 1 organ with Detection never above 30
• Many Mutations: hold 10 different traits in a single run
• Wake the Giant: raise the immune system to level 5 in a single run
• Golden Day: destroy 1 Legendary cell or better
• Escalation: face a generation 3 Killer T cell in a single run

Weekly Normal pool

12 challenges

One of these is the Normal weekly.

• Weekly Outbreak: destroy 1,000 cells
• Weekly Rounds: clear 80 rooms
• Weekly Mutations: take 40 traits
• Weekly Haul: find 15 pieces of gear
• Workshop Week: enhance gear 5 times
• Puzzle Week: solve 6 receptor puzzles
• Orb Week: collect 20 mutation orbs
• Vesicle Week: open 20 vesicle chests
• Ambush Week: destroy 60 cells before they notice you
• Explorer Week: discover 80 rooms
• Resistance Week: destroy 60 drug or vaccine particles
• Trophy Week: find 2 boss set pieces

Weekly Hard pool

12 challenges

One of these is the Hard weekly.

• Boss Week: defeat 5 bosses
• Spotless Week: clear 20 fights without taking damage
• Elite Week: destroy 40 elite cells
• Killer Week: destroy 3 Killer T cells
• Siege Week: survive 3 Immune Sieges
• Tumor Week: destroy 3 tumors
• Stealth Week: leave 3 organs with Detection never above 30
• Cartography Week: fully explore 4 organs
• Obsession Week: stack one trait ×5 in a single run
• Rival Week: defeat 2 rival viruses
• Mutation Week: mutate gear 1 time
• Purple Purge: destroy 15 Epic cells or better

Weekly Elite pool

10 challenges

One of these is the Elite weekly, worth an Epic gear piece and a skill point.

• Deep Dive: reach organ 5 in a single run
• Massacre: destroy 400 cells in a single run
• Back to Back: defeat 3 bosses in a single run
• Rival Season: defeat 3 rival viruses
• Epic Hunt: find 3 purple-or-better gear pieces
• Weekly Victory: win 1 run
• Flawless Bosses: defeat 2 bosses without taking damage
• Total War Week: raise the immune system to level 8 in a single run
• Myth Hunt: destroy 1 Mythic cell or better
• Swiss Army Week: hold 14 different traits in a single run