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Know your enemy

First Responders

The Immune Cells: First Responders

The host's white blood cells, antibodies and clotting fragments that fill every fight, from the Nasal Passage to the Brain. Each has its own way of hunting you, and any of them but the antibodies can show up as an elite.

On this page13
  1. Neutrophil
  2. Free Antibody
  3. Monocyte
  4. B Cell
  5. Macrophage
  6. Plasmablast
  7. Basophil
  8. Eosinophil
  9. Platelets
  10. Natural Killer Cell
  11. Dendritic Cell
  12. Complement System
  13. Memory B Cell

The usual first responder: a fast swarmer that rushes straight at you, weaving side to side, and hurts on contact. Weak alone, dangerous in packs.

  • Base stats: 30 health · 135 speed · 8 touch damage
  • No ranged attack; it only hurts by touching you
  • Organs: Nasal Passage, Lungs, Bloodstream, Gut, Liver, Bone Marrow
  • Also arrives in every hunter squad, in Antiviral and Interferon doses, as Mast Cell and Alveolar Macrophage reinforcements, from Hematopoietic Stem Cell summons, and 3 at a time when a Myeloblast dies
  • A Stem Cell Niche hazard releases two fresh neutrophils when you burst it
From the Codex

The most abundant white blood cell and a first responder. It has a multi-lobed nucleus and engulfs invaders.

Fun fact: Neutrophils can cast out sticky webs of DNA called NETs to trap microbes.

Neutrophil in the Codex

Tiny, fast and fragile Y-shaped antibodies that zig-zag straight at you and pop in one hit. A swarm joins every fight on top of the room's normal cells.

  • Base stats: 6 health · 215 speed (the fastest regular cell) · 4 touch damage
  • Every combat wave adds a swarm: up to about 5 in the first wave, 1–2 in reinforcement waves, more in deeper rooms and organs
  • Part of the normal cell mix in the Lymph Node, Gut and Brain
  • Plasmablasts keep budding more, and all three treatment doses bring big swarms
  • Never rolls an elite tier and never adapts in a Cytokine Storm
  • A kill raises Detection only a quarter as much as other cells and pays about a quarter of an ordinary cell's nucleotides (often none)
From the Codex

A Y-shaped protein made by B cells. Its two arms grab a specific part of a pathogen, marking it for destruction.

Fun fact: Your body can make billions of different antibodies, each one shaped for a different target.

Free Antibody in the Codex

Monocyte

Runner

Runs away from you, sliding along walls, and is worth chasing for its extra nucleotides. Pin it in a corner and it flashes red and turns on you.

  • Base stats: 48 health · 125 speed · 13 touch damage
  • Only bolts once you're well inside your auto-attack range, so you get shots in first
  • Wedged against a wall or corner while you're close: CORNERED! It hunts you hard and fast for about 3 seconds, then flees again (2.5 s before it can be cornered again)
  • Pays about 3.5x the nucleotides of an ordinary cell
  • Organs: Nasal Passage, Lungs, Bloodstream, Lymph Node, Liver, Bone Marrow, Brain
  • Also in Interferon doses and Hematopoietic Stem Cell summons
From the Codex

The largest white blood cell in the blood. Monocytes patrol, then leave the bloodstream and mature into macrophages.

Fun fact: About half of your body's monocytes wait in reserve in the spleen.

Monocyte in the Codex

B Cell

Ranged

Keeps its distance and fires antibody shots that slow you, sometimes three at once. Being slowed while others close in is how many runs end.

  • Base stats: 45 health · 85 speed · 6 touch damage
  • Holds 160–240 points away, strafing sideways
  • Fires every 1.3–2.3 s when it can see you within 420 points: one shot, or a 3-way spread about 1 time in 3
  • Each antibody hit slows you to 60% speed for about 1.6 s
  • Organs: Nasal Passage (from 2 rooms in), Lungs, Lymph Node
  • Also in every hunter squad, Booster Shot doses, Follicular Helper T Cell summons, and grown from Lymphoid Progenitors
From the Codex

A lymphocyte that makes antibodies tailored to a specific pathogen.

Fun fact: After an infection, memory B cells can stay in the body for years.

B Cell in the Codex

A big, tanky cell that creeps after you, then swells and charges to engulf you down a marked red line. Lots of health and very heavy contact damage.

  • Base stats: 140 health · 64 speed · 18 touch damage (the toughest common cell of the early organs)
  • Every 1.4–2.4 s, when you're within 320 points and in sight: a 0.6 s wind-up (it swells and keeps creeping forward) behind a red warning line, then a straight charge that can't turn. The charge is sized to reach you: as far as you were when it wound up, plus 40 points (120–520 points), always in 0.42 s
  • Organs: Nasal Passage (from 2 rooms in), Lungs, Bloodstream, Gut, Liver
  • Joins every hunter squad from the Lungs on
  • Pays 2.5x the nucleotides of an ordinary cell
  • Captured by a Retrovirus, a macrophage becomes a bodyguard that taunts nearby cells onto itself
From the Codex

A large white blood cell that eats pathogens and dead cells by phagocytosis, then shows pieces of them to other immune cells.

Fun fact: The name comes from Greek for "big eater".

Macrophage in the Codex

Plasmablast

Summoner

Hangs back at range and keeps budding fresh antibodies. Ignore it and the swarm never ends.

  • Base stats: 70 health · 48 speed · 10 touch damage
  • Keeps 260–380 points away
  • Buds a batch of 2 antibodies every few seconds (faster in deeper organs), up to 10 alive at once
  • Each elite tier adds one antibody per batch, a bigger cap and faster budding
  • About 1 in 5 plasmablasts (more often on elites) is a rapid budder that pulses visibly and buds almost twice as fast
  • Budded antibodies stay when it dies, but no more come
  • Organs: Nasal Passage (from 2 rooms in), Lungs, Bloodstream, Lymph Node, Bone Marrow; also in Booster Shot doses and Follicular Helper T Cell summons
From the Codex

An early plasma cell: an activated B cell that pours out antibodies within days of an infection.

Fun fact: One plasma cell can release thousands of antibody molecules every second.

Plasmablast in the Codex

Basophil

Buffer

Weak but pushy: it chases you and pulses histamine that riles up every cell nearby and makes you swell up. When it dies, its heparin dissolves nearby clots.

  • Base stats: 55 health · 68 speed · 6 touch damage
  • Histamine pulse every 3.5–4.8 s, radius 200: cells inside move 35% faster and hit 30% harder for 2.5 s
  • If you're inside the pulse you're SWOLLEN: slowed to 60% speed for 1.2 s
  • On death, heparin dissolves every platelet clot within 220 points (HEPARIN: CLOTS DISSOLVED)
  • Organs: Nasal Passage (from 2 rooms in), Bloodstream, Lymph Node
From the Codex

The rarest white blood cell. Its dark granules hold histamine, the alarm signal behind allergies, and heparin, which stops blood from clotting.

Fun fact: Basophils make up less than 1% of your white blood cells, yet help trigger severe allergic reactions.

Basophil in the Codex

A mortar cell that keeps its distance and lobs three toxic granules at where you're heading. They land on warning circles and leave acid pools that burn anything inside, other cells included.

  • Base stats: 65 health · 70 speed · 8 touch damage
  • Keeps 200–300 points away; fires every 1.6–2.4 s when you're within 480
  • Leads its aim: one granule lands where you're going, two scatter around it
  • Each granule lands after 0.8 s on a warning circle and leaves an acid pool for 3 s
  • Acid burns you while you stand in it, and burns immune cells too (10 damage per second): lure them in
  • Organs: Lungs, Gut, Bone Marrow
From the Codex

A granulocyte packed with toxic orange-red granules it sprays at parasites too big to swallow. It also drives the swelling in asthma and allergies.

Fun fact: Eosinophils are named for eosin, the pink-orange dye their granules soak up under the microscope.

Eosinophil in the Codex

Small, fast clotting fragments that clump together and swarm you. Every one that dies leaves a sticky fibrin clot on the floor.

  • Base stats: 12 health · 150 speed · 4 touch damage
  • Steer toward you and toward each other, arriving in clumps
  • On death they leave a sticky clot for 7 s that slows you to 20% speed (the strongest slow in the game)
  • The Plasminogen Activator gene stops clots slowing you; a dying Basophil dissolves them
  • Organs: Bloodstream (very common), Bone Marrow
  • Also: 3 per hunter squad from the Bloodstream on, Plasma Cell swarms (7, or 10 enraged), Megakaryocyte broods, and Hematopoietic Stem Cell summons (8)
From the Codex

Tiny cell fragments in the blood that clump together and plug wounds, forming clots with fibrin.

Fun fact: Platelets also help the immune system: they can trap bacteria and viruses and release antimicrobial proteins.

Platelets in the Codex

Stalks you, then swells up and blasts perforin in a wide ring around itself for heavy damage. Back off or dash away when it swells.

  • Base stats: 80 health · 100 speed · 12 touch damage
  • Within 120 points it winds up for 0.65 s (swelling, with a red warning circle)
  • Perforin burst: radius 115, 20 base damage, then a 2.6 s cooldown
  • Organs: Bloodstream, Lymph Node, Brain
  • Also in hunter squads from the Bloodstream on, Interferon doses (the core of the dose), Plasma Cell reinforcements, Hematopoietic Stem Cell summons, and grown from Lymphoid Progenitors
From the Codex

An innate lymphocyte that kills virus-infected and cancerous cells without needing prior training, using perforin and granzymes.

Fun fact: NK cells spot infected cells partly by what's missing: many viruses hide the cell's MHC markers, and NK cells notice.

Natural Killer Cell in the Codex

Never attacks: it keeps its distance and studies you, glowing brighter. Let it watch you for 2.5 seconds and it presents your antigen to the whole immune system, then keeps doing it every 4 seconds until it dies.

  • Base stats: 60 health · 85 speed · no touch damage
  • Backs away inside 260 points, otherwise circles you
  • First presentation: counts while it can see you within 420 points; breaking line of sight pauses the count
  • ANTIGEN PRESENTED: Detection jumps by 18 and every unaware cell in the room is alerted
  • After that it presents again every 4 s for as long as it lives, whether it can see you or not (Latency and other hiding still pause it)
  • A badge over its head shows it: an eye with a ring filling while it studies you, then a pulsing gold "!" with the ring counting to the next presentation
  • Organs: Bloodstream, Lymph Node
From the Codex

A sentinel cell with long branching arms that captures pathogens and presents their pieces (antigens) to T cells.

Fun fact: Dendritic cells are the bridge between innate and adaptive immunity; their discoverer won a Nobel Prize in 2011.

Dendritic Cell in the Codex

A stationary protein cluster that fires slow homing orbs whenever it can see you.

  • Base stats: 70 health · never moves · 6 touch damage
  • Fires every 2.4 s when you're within 420 points and in sight
  • Orbs deal 9 damage, fly slowly and curve after you for up to 5 s
  • Never gives up the hunt once alerted
  • Can't roll the Swift, Enraged or Splitting affixes
  • Organs: Bloodstream, Gut, Liver
From the Codex

A cascade of blood proteins that tag pathogens and assemble the membrane attack complex, a pore that punches holes in membranes.

Fun fact: There are over 30 complement proteins, and they make up about 10% of the proteins in your blood.

Complement System in the Codex

Remembers you: the moment it spots you it fires a fast aimed burst, then steady aimed volleys. It also remembers the last shot type that hit it.

  • Base stats: 80 health · 75 speed · 7 touch damage
  • REMEMBERS YOU: on first spotting you (within 460 points), a rapid 6-shot stream aimed where you're going
  • Then a 3-shot aimed spread every 2.2–3.2 s while it can see you
  • Takes half damage from the last shot type that hit it until a different type lands (REMEMBERED)
  • Keeps 240–340 points away
  • Organs: Bloodstream, Lymph Node, Brain
From the Codex

A long-lived B cell left over from an earlier infection. It remembers the invader and answers much faster and harder the next time.

Fun fact: Memory B cells are why vaccines work: they keep the recipe for the right antibody for years, sometimes decades.

Memory B Cell in the Codex

See also