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Every run feeds your lineage. Earn XP and levels, spend points across a three-branch skill tree, upgrade the Petri Lab, load run modifiers and chase hundreds of challenges, while new mechanics arrive one level at a time.
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Level upXP & LevelsEvery Infect Game Mode run earns XP for your lineage. XP raises your level, and each level pays out skill points for…9
Skill treeSkill TreeThree trees of 21 skills each (63 in all): Replication, Transmission and Persistence. Each has three columns, its own…9Skill tree · Tree 1Replication TreeOffence. Copy faster than the immune system can respond: build Viral Load by hitting cells, then cash it in. Resource…18Skill tree · Tree 2Transmission TreeMovement and stealth. Spread fast, hit from where the immune system isn't looking, and keep Detection low. Resource…18Skill tree · Tree 3Persistence TreeSurvival. Endure, recover and come back stronger: store damage you take and turn it into healing. Resource: Reservoir…18Skill tree · CapstonesCapstonesEach tree ends in three capstones, one under each column. They open at 21 points in the tree, and you can own only one…9
Petri LabPetri LabSpend nucleotides on permanent upgrades in three sections: Core Genome, Signature Ability and Ultimate. Opens at level…29
Run modifiersRun ModifiersOpen at level 8. Craft one-run modifiers with nucleotides and materials, then load up to 3 (one of each) before a run…32Run modifiersModifier CombosLoading certain modifiers together unlocks a combo bonus on top of their own effects: 17 pairs and 15 trios that fill…34
ChallengesChallengesThe Challenges screen opens at level 3. It has daily and weekly challenges plus 637 permanent milestone challenges…9ChallengesDaily & Weekly ChallengesDailies and weeklies are drawn from these pools, one per difficulty.6
ChallengesMilestone Challenges637 permanent challenges in 11 groups. Chains climb in difficulty as their targets grow (E = Easy, N = Normal, H =…11
Unlock scheduleMechanic UnlocksA new save isn't buried in systems on run one. Each in-run mechanic unlocks for the whole save when any virus reaches…14Unlock scheduleFeature UnlocksThe main menu starts with just Infect a Host and grows one feature at a time, showing only the next locked one as a…22
Reached organsReached OrgansYour lineage remembers the deepest organ it has reached. Reaching a new organ for the first time opens deeper skill…12
ResourcesCurrencies & MaterialsNucleotides pay for most things; RNA and Ribozyme Cores are rare drops tied to Pandemic Game Mode and Endless Game Mode.11Key numbers
| Skill tree nodes | 63 |
|---|---|
| Skill tree branches | 3 (Replication, Transmission, Persistence) |
| Total skill ranks | 145 |
| Skill points to max the whole tree | 145 (one capstone per tree) |
| Capstones | 9 (3 per tree, own 1 per tree) |
| Active skills | 3 |
| Skill tree row gates | 0 to 21 points in the tree; level 1 to 23, 0 to 10 generations, organs 1 to 8 |
| XP per Infect run | 1 per 3 kills + 8 per room + 150 for a victory |
| XP to reach level 10 | 2,640 |
| XP to reach level 50 | 189,200 |
| Skill points from levels by level 50 | 128 |
| Bonus skill points from organ challenges | 32 |
| In-run mechanics unlocked by level | 13 (12 by level, 1 at generation 2) |
| Level & lineage milestones | 12 |
| Petri Lab upgrades | 26 (11 to 13 per virus) |
| Highest Petri Lab upgrade level | 40 |
| RNA to unlock every advanced Lab upgrade | 22 |
| Run modifiers | 30 |
| Modifier combos | 32 (17 pairs, 15 trios) |
| Modifiers loaded per run | 3 |
| Milestone challenges | 637 in 11 categories |
| Daily challenge pool | 46 (3 per day) |
| Weekly challenge pool | 34 (3 per week) |
| Challenge difficulties | 5 |
| Virus adaptations (organ milestones) | 11 |
| Currencies & materials | 4 nucleotides, RNA, 3 enhancement materials, rare DNA |