
Organ 6 of 8
Liver
The body's filter. Rust-red hexagonal lobules, each with a dark central vein, patrolled by near-invisible NKT cells and stellate cells that leave scar tissue behind.

Who you meet here
BossKupffer CellThe liver's resident filter, a lumpy macrophage that nets you in crossing lashes, engulfs you and charges. It attacks…
Key guardianPolyploid HepatocyteA two-nucleus liver cell (Awakened) guarding the Fusion Peptide. Its rings turn toxic one after another.
GeneFusion PeptideSlips through tight junctions. Your dash damages cells you pass through.
CancerHepatocellular CarcinomaA liver tumor fed by satellite lobes through pulsing vessels. Kill every lobe before the first regrows and the core…
AssassinHepatoid RegeneratorA hexagonal cell threaded with green bile. Leave it alone for a moment and it heals itself.Organ facts
- Objective
- "Survive the Kupffer Cell's filter"
- Boss
- Kupffer Cell, "The liver's resident filter"
- Key guardian
- Polyploid Hepatocyte (Awakened), holding the Fusion Peptide
- Cancer
- Hepatocellular Carcinoma (it regenerates from its lobes, so kill every lobe before they regrow, then strike). Its assassin is the Hepatoid Regenerator
- Hazards
- bile ducts that spray jets across the room
- Local cells
- Neutrophils, Stellate Cells, NKT Cells, Macrophages, Monocytes and Complement. Deeper rooms add IgA Plasma Cells, antiviral capsules and vaccine vials
- Look
- a dark rust floor tiled with hexagonal lobules and central veins, inside walls of hepatocyte plates, rows of boxy cells with round nuclei
- Music
- B minor at 104 BPM, a triangle pad under a sawtooth lead
- Size
- 20–24 rooms
- Threat
- enemy damage ×7.5, enemy health ×19, rewards ×4
Also in the Liver
Tissue Hazards & TerrainOrgans & Bosses
Bile DuctsDucts in the walls spray a corrosive jet of bile straight across the room after a flashing warning line.Liver
Clots & Scar TissueSticky patches of clot left by dying platelets, fibrin attacks, goblet mucus and stellate scarring. They bog you right down.Bloodstream & deeperTumor PartsCancer
Liver coreA dark red-brown mass built of hexagonal lobules flecked with green bile, fed by its lobes.Liver
Satellite lobeA smaller hexagonal nodule joined to the core by a pulsing vessel. It feeds the core and spits bile.LiverTumor AttacksCancer
Bile arcsGlobs of bile lobbed at you and around you, each landing in a warned circle and leaving a bile puddle.Liver
Bile sprayA line of 7 bile splashes sweeping out from the core toward you.Liver
Bile gobEach satellite lobe spits a slow green gob of bile at you.Liver
CirrhosisBring every lobe down at the same time and the liver tumor's regeneration breaks.Liver weak pointOrgan MilestonesViruses
The Organ MapIn a Run
Boss SetsGear & Store
Audio & PresentationGame Modes
Found in every organ
From the Codex
The body's chemical factory and filter. Blood from the gut flows through its hexagonal lobules, where resident macrophages catch anything foreign.
Fun fact: The liver can regrow from as little as a quarter of its original size.
Liver in the Codex











