
Organ 4 of 8
Lymph Node
The immune system's checkpoint: blue follicles crowded with lymphocytes and organised by helper T cells. From here on, each organ is much harder than the last.

Who you meet here
BossFollicular Helper T CellCommander of the germinal centre: a bristling blue lymphocyte that whips the whole room into a cytokine storm and…
Key guardianReticular WardenA star-shaped scaffold cell (Awakened) guarding the Plasminogen Activator. It strings a cage of conduit threads around…
GenePlasminogen ActivatorDissolves fibrin clots. Platelet clots no longer slow you.
CancerLymphomaA germinal centre in a crowd of identical lymphocytes. Most are harmless, but lymphoma clones hide among them, and the…
AssassinOwl-Eye MimicInstead of cloaking it looks like an ordinary lymphocyte, until it gets close and shows its owl-eyed twin nuclei and…Organ facts
- Objective
- "Break the Follicular Helper T Cell's command"
- Boss
- Follicular Helper T Cell, "Commander of the germinal centre"
- Key guardian
- Reticular Warden (Awakened), holding the Plasminogen Activator
- Cancer
- Lymphoma (clones hide among harmless lymphocytes, and the germinal centre is only vulnerable while it swells). Its assassin is the Owl-Eye Mimic
- Hazards
- reticular fibres strung across the rooms
- Local cells
- Free Antibodies, B Cells, Helper T Cells, Plasmablasts, NK Cells, Monocytes, Thymocytes, Lymphoid Progenitors and Basophils. Deeper rooms add Follicular Dendritic Cells, Dendritic Cells, vaccine vials and Memory B Cells
- Look
- a navy floor with pale follicle rings and lymphocytes drifting past, inside a fibrous capsule of collagen strands dotted with fibroblasts
- Music
- C-sharp Dorian at 108 BPM, swung
- Size
- 18–22 rooms
- Threat
- enemy damage ×2, enemy health ×4, rewards ×2.8
Also in the Lymph Node
Tissue Hazards & TerrainOrgans & Bosses
Reticular FibresFibres strung across the node. Touching one slows you to under a third of your speed, and cells get snagged too.Lymph Node
Clots & Scar TissueSticky patches of clot left by dying platelets, fibrin attacks, goblet mucus and stellate scarring. They bog you right down.Bloodstream & deeperTumor PartsCancer
Harmless lymphocyteAn ordinary small lymphocyte drifting around the follicle. It never attacks, but it looks exactly like a lymphoma clone.Lymph Node
Lymphoma cloneA cancer cell wearing a harmless lymphocyte's face. Get close or hit it and it shows its swollen, notched nucleus (CLONE!) and hunts you.Lymph Node
Germinal centreThe lymphoma core: a lymph follicle gone wrong, with a dark mantle of packed cells around a pale, swollen centre.Lymph NodeTumor AttacksCancer
Scan pulseA pink ring rolls out from the germinal centre; every hidden clone it passes briefly shows its true face.Lymph Node
Swell & splitThe germinal centre swells, flashing, with a ring growing round it, then splits with a ring of shots and two new cells.Lymph NodeAdaptive ImmunityImmune System
Organ MilestonesViruses
Retrovirus: Lymph NodeCaptured cells hit 25% harder and are 25% tougher.Organ 4
Halovirus: Lymph NodeInfection, spike volleys, outbreaks and the ultimate hit 80% harder.Organ 4The Organ MapIn a Run
The HUDIn a Run
Boss SetsGear & Store
Glycan ShieldThe Follicular Helper T Cell's set, built for stealth and ambushes.Organ 4 · Lymph NodeAudio & PresentationGame Modes
Found in every organ
From the Codex
A bean-sized checkpoint where immune cells gather. Lymph drains through it, and B and T cells meet the antigens dendritic cells bring in.
Fun fact: You have around 600 lymph nodes; swollen glands during a cold are nodes busy fighting.
Lymph Node in the Codex












