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Signature effects

Unique Abilities

Eight signature effects. They roll on Legendary (1), Mythic (2) and Prismatic (3) gear, and a Bonus ability mutation can add one to a piece of any tier. Uniques show in orange on the piece.

On this page8
  1. Volatile Payload
  2. Barbed Coat
  3. Twin Genome
  4. Guardian Membrane
  5. Primed Replicase
  6. Parasitic Uptake
  7. Phantom Antigens
  8. Overdrive Polymerase

Dying cells burst and hurt their neighbours.

  • Bosses don't burst
From the Codex

Lytic viruses burst their host cells, releasing virions and inflammatory debris all at once.

Lysis Cascade in the Codex

Cells that touch you take 20 damage.

  • Stacks: two pieces with it deal 40
From the Codex

Some viral proteins damage the membranes of immune cells that try to grab them.

Barbed Spikes in the Codex

+1 projectile on every shot (40% damage).

  • Stacks with other pieces that have it
From the Codex

Gene duplication gives a virus a spare copy of a gene that can take on a new job.

Twin Genome in the Codex

Start each run with Shift (Latency for Retrovirus) and your ultimate charged.

From the Codex

Strong promoters can switch a virus's genes on faster and louder than usual.

Overcharged in the Codex

Auto-attacks heal 1% of their damage.

  • Adds to lifesteal from stats; total lifesteal is capped at 3% of damage
From the Codex

Viruses reprogram cell metabolism to siphon off nutrients and building blocks for themselves.

Vampiric Uptake in the Codex

See also